P01-012 – Evaluation of autonomic function in FMF

Introduction Familial Mediterranean fever (FMF) is characterized by acute and recurrent attacks of fever and polyserositis. It is associated with conduction disturbances and rhythm abnormalities. Heart rate variability (HRV) is the term used to indicate the fluctuation in cardiac frequency over time. HRV analysis is used to evaluate the condition of the autonomous nervous system, which regulates general cardiac condition and cardiac activity. Significant correlations between cardiovascular mortality and the autonomous nervous system have been evidenced in the last twenty years. In adult FMF patients abnormal heart rate variability (HRV) parameters were found, suggesting to autonomic dysfunction.